4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

Base Information

Chemical Name:4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide
CAS No.:1572927-77-5
Molecular Formula:C₂₁H₂₇N₅O₄S₂
Molecular Weight:477.608
Hs Code.:

Synonyms:4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

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Chemical Property of 4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

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Technology Process of 4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

There total 23 articles about 4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-53-0
tert-butyl (5-((4-(4-((1-methylethyl)sulfamoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572927-77-5
4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

: 1572927-78-6
4-(2R)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h; Overall yield = 80 mg;

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1572927-77-5
4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 80 - 100 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 20 °C

4.1: pyridine / dichloromethane / 0.08 h / 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: carbon dioxide; ammonia / methanol

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluorormethanesulfonic acid; carbon dioxide; ammonia; trifluoroacetic acid; johnphos; sodium t-butanolate; In methanol; dichloromethane; toluene;
DOI:10.1021/jm5000497

Reference yield:

: 1361224-49-8
benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-oxo-3-pentyn-1-yl)-carbamate

: 1572927-77-5
4-(2S)-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)-N-(1-methylethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / -10 - 20 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 2.17 h / 20 °C

3.1: johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 80 - 100 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 20 °C

5.1: pyridine / dichloromethane / 0.08 h / 20 °C

5.2: 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: carbon dioxide; ammonia / methanol

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluorormethanesulfonic acid; carbon dioxide; ammonia; sodium tris(acetoxy)borohydride; trifluoroacetic acid; johnphos; sodium t-butanolate; In methanol; dichloromethane; toluene;
DOI:10.1021/jm5000497