(1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

Base Information

• Chemical Name: (1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane
• CAS No.: 118724-77-9
• Molecular Formula: C₁₇H₂₄BrNO₂
• Molecular Weight: 354.287

Synonyms:(1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

Chemical Property of (1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

There total 1 articles about (1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(1S,3R,5R)-5-(3-Methoxy-phenyl)-8-methyl-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-oxa-8-aza-bicyclo[3.3.1]nonane; hydrochloride (118724-76-8) → (1S*,3S*,5S*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane (118724-77-9)

Guidance literature:

With bromine; triphenylphosphine; In tetrahydrofuran; at 10 - 20 ℃; for 0.25h;

DOI:10.1021/jo00267a039

Reference yield:

(1S*,3S*,5S*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane (118724-77-9) → 2-methyl-4aα-(3-methoxyphenyl)-1,2,3,4,4a,5,6,7,8,8aβ-decahydro-6β-isoquinolinol (61528-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 10.8 g / TFA / 1 h / Ambient temperature

2: K₂CO₃ / acetonitrile / 2 h / Heating

3: 1.) K₂CO₃, MeOH, 2.) H₂ / 2.) PtO₂ / 1.) EtOH, 60 psi, 16 h, 2.) RT, 2 h

With methanol; hydrogen; potassium carbonate; trifluoroacetic acid; platinum(IV) oxide; In acetonitrile;

DOI:10.1021/jo00267a039

Reference yield:

(1S*,3S*,5S*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane (118724-77-9) → 2-methyl-4aα-(3-methoxyphenyl)-1,2,3,4,4a,5,6,7,8,8aα-decahydro-6-oxoisoquinoline (61528-05-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 10.8 g / TFA / 1 h / Ambient temperature

2: K₂CO₃ / acetonitrile / 2 h / Heating

3: K₂CO₃, MeOH / 2 h / Ambient temperature

4: 73 percent / H₂ / PtO₂ / ethanol; acetic acid / 16 h / 3102.9 Torr

5: 84 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -55 °C

With methanol; oxalyl dichloride; hydrogen; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; platinum(IV) oxide; In ethanol; dichloromethane; acetic acid; acetonitrile;

DOI:10.1021/jo00267a039

upstream raw materials:

(1S,3R,5R)-5-(3-Methoxy-phenyl)-8-methyl-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-2-oxa-8-aza-bicyclo[3.3.1]nonane; hydrochloride

Downstream raw materials:

Acetic acid (R)-3-bromo-1-[(R)-4-(3-methoxy-phenyl)-1-methyl-1,2,3,4-tetrahydro-pyridin-4-ylmethyl]-propyl ester

3-(3-methoxyphenyl)-6-methyl-11-oxa-6-azatricyclo<5.3.1.0^3,8>undecane

2-methyl-4aα-(3-methoxyphenyl)-1,2,3,4,4a,5,6,7,8,8aα-decahydro-6β-isoquinolinol

2-methyl-4aα-(3-methoxyphenyl)-1,2,3,4,4a,5,6,7,8,8aβ-decahydro-6β-isoquinolinol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 118724-77-9 (1S^*,3S^*,5S^*)-3-(2-bromoethyl)-5-(3-methoxyphenyl)-8-methyl-2-oxa-8-azabicyclo<3.3.1>nonane

Send

Send

Metric Ton KG G Pound L ML

Send

Send