(S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

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Chemical Name:(S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester
CAS No.:143687-51-8
Molecular Formula:C₂₉H₄₈N₂O₄
Molecular Weight:488.711
Hs Code.:

Synonyms:(S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

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Chemical Property of (S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

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Technology Process of (S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

There total 7 articles about (S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 143677-67-2
(E)-6-Oxo-hex-4-enoic acid diethylamide

: 143730-56-7
Dimethyl-[(1S,2R)-1-methyl-2-phenyl-2-((E)-1-trimethylsilanyloxy-oct-1-enyloxy)-ethyl]-amine

: 143687-51-8
(S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 1.5h;
DOI:10.1016/0040-4020(92)80006-2

Reference yield:

: 1522-00-5
3-(N,N-diethylcarbamoyl)propionic acid

: 143687-51-8
(S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / BH₃-Me₂S / CH₂Cl₂; tetrahydrofuran / 3 h / 25 °C

2: 1) ClCO-COCl, DMSO, 2) NEt₃ / 1) CH₂Cl₂, -70 deg C, 2) -30 to 0 deg C

3: 82 percent / benzene / 8 h / Heating

4: 50 percent / TiCl₄ / CH₂Cl₂ / 1.5 h / -78 °C

With oxalyl dichloride; dimethylsulfide borane complex; titanium tetrachloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/0040-4020(92)80006-2

Reference yield:

: 92442-09-6
3-Formyl-propionsaeure-diethylamid

: 143687-51-8
(S)-2-((E)-(S)-5-Diethylcarbamoyl-1-hydroxy-pent-2-enyl)-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / benzene / 8 h / Heating

2: 50 percent / TiCl₄ / CH₂Cl₂ / 1.5 h / -78 °C

With titanium tetrachloride; In dichloromethane; benzene;
DOI:10.1016/0040-4020(92)80006-2