Technology Process of 1-benzyl-2-butylpyrrolidine
There total 8 articles about 1-benzyl-2-butylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
n-butylcopper; 1-benzyl-5-methylsulfanyl-3,4-dihydro-2H-pyrrolium iodide;
In
tetrahydrofuran; dichloromethane;
for 1h;
Cooling with acetone-dry ice;
With
sodium tris(acetoxy)borohydride;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/acs.joc.7b02150
- Guidance literature:
-
1-benzyl-2-pyrrolidone;
With
2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -78 - 0 ℃;
for 1h;
Inert atmosphere;
halo(butyl)magnesium;
In
diethyl ether; dichloromethane;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
With
lithium aluminium tetrahydride;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jo4007656
- Guidance literature:
-
1-benzyl-2-pyrrolidone;
With
2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -78 ℃;
for 0.75h;
n-butyl magnesium bromide;
In
diethyl ether; dichloromethane;
at -78 - 20 ℃;
for 1h;
With
lithium aluminium tetrahydride;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1002/chem.201002054
