((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
CAS No.:1374884-20-4
Molecular Formula:C₂₆H₂₉F₂N₅O₃
Molecular Weight:497.545
Hs Code.:

Synonyms:((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Chemical Property of ((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

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Technology Process of ((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

There total 3 articles about ((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 819057-45-9
3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine

: 1373165-26-4
((S)-1-{(S)-2-[4-(4-bromo-3-fluoro-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

: 1374884-20-4
((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In water; ethyl acetate; toluene;

Reference yield:

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1374884-20-4
((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / ethyl acetate; N,N-dimethyl-formamide

2: potassium carbonate / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / ethyl acetate; toluene; water

With potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1374884-20-4
((S)-1-{(S)-2-[4-(4'-amino-2,2'-difluoro-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; NaOH / water

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / ethyl acetate; N,N-dimethyl-formamide

3: potassium carbonate / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / ethyl acetate; toluene; water

With hydrogenchloride; NaOH; potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In water; ethyl acetate; N,N-dimethyl-formamide; toluene;