(2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Chemical Name:(2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
CAS No.:145473-27-4
Molecular Formula:C₂₅H₃₁NO₁₁S
Molecular Weight:553.587
Hs Code.:

Synonyms:(2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Chemical Property of (2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Technology Process of (2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 3 articles about (2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 145473-26-3
methyl N-(carbobenzyloxy)-4-hydroxy-5-(1',2',3',4'-tetrahydroxybutyl)prolinate

: 98-59-9
p-toluenesulfonyl chloride

: 145473-27-4
(2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: With pyridine; at 4 ℃;
DOI:10.1021/jo00053a051

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 145473-27-4
(2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / H₂O / Ambient temperature

2: acetyl chloride / 3 h / Ambient temperature

3: 72 percent / pyridine / 4 °C

With pyridine; sodium hydrogencarbonate; acetyl chloride; In water;
DOI:10.1021/jo00053a051

Reference yield:

: (4S,5R)-4-Hydroxy-5-((1R,2S,3R)-1,2,3,4-tetrahydroxy-butyl)-pyrrolidine-2-carboxylic acid

: 145473-27-4
(2R,4S,5R)-4-Hydroxy-5-[(1R,2S,3R)-1,2,3-trihydroxy-4-(toluene-4-sulfonyloxy)-butyl]-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / H₂O / Ambient temperature

2: acetyl chloride / 3 h / Ambient temperature

3: 72 percent / pyridine / 4 °C

With pyridine; sodium hydrogencarbonate; acetyl chloride; In water;
DOI:10.1021/jo00053a051