Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

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Chemical Name:Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester
CAS No.:845306-67-4
Molecular Formula:C₃₃H₃₉NO₆
Molecular Weight:545.676
Hs Code.:

Synonyms:Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

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Chemical Property of Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

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Technology Process of Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

There total 8 articles about Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 845306-66-3
3-(5,5-dimethyl-1,3-dioxan-2-yl)-5-(1-phenylethylamino)pentyl benzoate

: 845306-67-4
Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.0833333h;
DOI:10.1002/ejoc.200400615

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 845306-67-4
Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / TMSOTf / CH₂Cl₂ / 18 h / 20 °C

2: 97 percent / LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

3: 58 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

4: 97 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 20 °C / Swern oxidation

5: ethanol / 2 h / 20 °C

6: 1.68 g / NaBH₄ / methanol / 1 h / 20 °C

7: 92 percent / iPr₂EtN / CH₂Cl₂ / 0.08 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1002/ejoc.200400615

Reference yield:

: 2117-23-9
2, 2, 5, 5, 8, 8-hexamethyl-3, 7-dioxa-2, 8-disilanonane

: 845306-67-4
Benzoic acid 2-(2-{2-[benzyloxycarbonyl-((R)-1-phenyl-ethyl)-amino]-ethyl}-5,5-dimethyl-[1,3]dioxan-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / TMSOTf / CH₂Cl₂ / 18 h / 20 °C

2: 97 percent / LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

3: 58 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

4: 97 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 20 °C / Swern oxidation

5: ethanol / 2 h / 20 °C

6: 1.68 g / NaBH₄ / methanol / 1 h / 20 °C

7: 92 percent / iPr₂EtN / CH₂Cl₂ / 0.08 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1002/ejoc.200400615