Pentaleno[2,1-c]isoxazole, 3,3a,3b,4,5,6,6a,7-octahydro-, (3a-alpha-,3b-ba-,6a-ba-)- (9CI)

Base Information

• Chemical Name: Pentaleno[2,1-c]isoxazole, 3,3a,3b,4,5,6,6a,7-octahydro-, (3a-alpha-,3b-ba-,6a-ba-)- (9CI)
• CAS No.: 155750-44-0
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Mol file: 155750-44-0.mol

Synonyms:Pentaleno[2,1-c]isoxazole, 3,3a,3b,4,5,6,6a,7-octahydro-, (3a-alpha-,3b-b閠a-,6a-b閠a-)- (9CI);Pentaleno[2,1-c]isoxazole,3,3a,3b,4,5,6,6a,7-octahydro-,(3a-alpha-,3b-bta-,6a-bta-)-(9CI)

Chemical Property of Pentaleno[2,1-c]isoxazole, 3,3a,3b,4,5,6,6a,7-octahydro-, (3a-alpha-,3b-ba-,6a-ba-)- (9CI)

Chemical Property:

• Boiling Point: 227.1±23.0 °C(Predicted)
• Density: 1.46±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentaleno[2,1-c]isoxazole, 3,3a,3b,4,5,6,6a,7-octahydro-, (3a-alpha-,3b-ba-,6a-ba-)- (9CI)

There total 8 articles about Pentaleno[2,1-c]isoxazole, 3,3a,3b,4,5,6,6a,7-octahydro-, (3a-alpha-,3b-ba-,6a-ba-)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-8-hydroxy-6-octanoic acid lactone (41979-97-9) → (3aR,3bR,6aR)-3,3a,3b,4,5,6,6a,7-Octahydro-2-oxa-1-aza-cyclopenta[a]pentalene (155750-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.) LAH

2: 1.) PCC, 2.) KF, 3.) Ac₂O, DMAP, 4.) NaBH₄

3: p-chlorophenylisocyanate, Et₃N / tetrahydrofuran

4: Ambient temperature

With dmap; potassium fluoride; sodium tetrahydroborate; lithium aluminium tetrahydride; acetic anhydride; p-chlorphenylisocyanate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran;

DOI:10.1246/cl.1994.63

Reference yield:

cis-1-hydroxymethyl-2-vinylcyclopentane (87734-78-9,90582-64-2,92216-62-1,92216-63-2,119067-64-0) → (3aR,3bR,6aR)-3,3a,3b,4,5,6,6a,7-Octahydro-2-oxa-1-aza-cyclopenta[a]pentalene (155750-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) PCC, 2.) KF, 3.) Ac₂O, DMAP, 4.) NaBH₄

2: p-chlorophenylisocyanate, Et₃N / tetrahydrofuran

3: Ambient temperature

With dmap; potassium fluoride; sodium tetrahydroborate; acetic anhydride; p-chlorphenylisocyanate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran;

DOI:10.1246/cl.1994.63

Reference yield:

(Z)-8-hydroxy-6-octanoic acid lactone (41979-97-9) → (3aS,3bR,6aR)-3,3a,3b,4,5,6,6a,7-Octahydro-2-oxa-1-aza-cyclopenta[a]pentalene (155750-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) LAH

2: 1.) PCC, 2.) KF, 3.) Ac₂O, DMAP, 4.) NaBH₄

3: p-chlorophenylisocyanate, Et₃N / tetrahydrofuran

With dmap; potassium fluoride; sodium tetrahydroborate; lithium aluminium tetrahydride; acetic anhydride; p-chlorphenylisocyanate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran;

DOI:10.1246/cl.1994.63

upstream raw materials:

(Z)-8-hydroxy-6-octanoic acid lactone

cis-1-hydroxymethyl-2-vinylcyclopentane