ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

Base Information

Chemical Name:ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate
CAS No.:1383478-75-8
Molecular Formula:C₁₉H₁₅N₇O₃S
Molecular Weight:421.439
Hs Code.:

Synonyms:ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

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Chemical Property of ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

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Technology Process of ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

There total 4 articles about ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1383478-73-6
2-[5-amino-4-cyano-3-(methylsulfanyl)-1H-pyrazol-1-yl]-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

: 122-51-0
orthoformic acid triethyl ester

: 1383478-75-8
ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

Guidance literature:: In acetic anhydride; for 2h; Reflux;
DOI:10.1007/s11164-012-0597-7

Reference yield:

: 893759-59-6
6-(4-hydroxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

: 1383478-75-8
ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 5 h / Reflux

2: triethylamine / methanol / Reflux

3: acetic anhydride / 2 h / Reflux

With hydrazine hydrate; triethylamine; In methanol; acetic anhydride;
DOI:10.1007/s11164-012-0597-7

Reference yield:

: 1383478-71-4
2-hydrazinyl-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

: 1383478-75-8
ethyl{1-[5-cyano-4-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]-4-isocyano-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / Reflux

2: acetic anhydride / 2 h / Reflux

With triethylamine; In methanol; acetic anhydride;
DOI:10.1007/s11164-012-0597-7