(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

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Chemical Name:(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
CAS No.:1344157-36-3
Molecular Formula:C₃₂H₄₅N₅O₁₀
Molecular Weight:659.737
Hs Code.:

(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Synonyms:(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

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Chemical Property of (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

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Technology Process of (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

There total 11 articles about (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344158-52-6
(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid

: C₁₇H₃₀N₅O₄Pol

: 1344158-30-0
(2S,3R)-3-para-tolyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-yl methyl) ester

: 1344157-36-3
(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: C₁₇H₃₀N₅O₄Pol; (2S,3R)-3-para-tolyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-yl methyl) ester; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 20h; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; solid phase reaction;

(S)-2-[(S)-2-((S)-2-acetylamino-3-methyl-butyrylamino)-3-tert-butoxycarbonyl-propionylamino]-3-methyl-butyric acid; Further stages;
DOI:10.1016/j.bmc.2011.08.020

Reference yield:

: 1344158-03-7
(2S,3R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-3-p-tolyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1344157-36-3
(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C

3.1: chromium(VI) oxide; sulfuric acid; water / acetone / 5 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

5.1: sodium carbonate / 1,4-dioxane; water / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C / solid phase reaction

6.2: 1 h / 20 °C / solid phase reaction

With chromium(VI) oxide; dimethylsulfide borane complex; sulfuric acid; tetrabutyl ammonium fluoride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2011.08.020

Reference yield:

: 1344158-17-3
(2S,3R)-2-hydroxymethyl-3-p-tolyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1344157-36-3
(S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-(p-tolyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: chromium(VI) oxide; sulfuric acid; water / acetone / 5 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

3.1: sodium carbonate / 1,4-dioxane; water / 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C / solid phase reaction

4.2: 1 h / 20 °C / solid phase reaction

With chromium(VI) oxide; sulfuric acid; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2011.08.020