(4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

Base Information

Chemical Name:(4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane
CAS No.:1352033-65-8
Molecular Formula:C₂₇H₃₀O₅
Molecular Weight:434.532
Hs Code.:

Synonyms:(4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

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Technology Process of (4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

There total 7 articles about (4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 1352033-64-7
(3S)-5-[4-(benzyloxy)-3-methoxyphenyl]pentane-1,3-diol

: 1352033-65-8
(4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.09.012

Reference yield:

: 1352033-61-4
ethyl (E)-5-[4-(benzyloxy)-3-methoxyphenyl]-2-pentenoate

: 1352033-65-8
(4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

1.2: Saturated solution

2.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / 3 h / -24 °C / Molecular sieve; Inert atmosphere

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene; 2.1: Sharpless epoxidation;
DOI:10.1016/j.tetasy.2011.09.012

Reference yield:

: 1352033-62-5
(E)-5-[4-(benzyloxy)-3-methoxyphenyl]-2-penten-1-ol

: 1352033-65-8
(4S)-4-[4-(benzyloxy)-3-methoxyphenethyl]-2-(4-methoxyphenyl)-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / 3 h / -24 °C / Molecular sieve; Inert atmosphere

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / Inert atmosphere

3: toluene-4-sulfonic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene; 1: Sharpless epoxidation;
DOI:10.1016/j.tetasy.2011.09.012