methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Base Information

Chemical Name:methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate
CAS No.:1596367-77-9
Molecular Formula:C₂₂H₁₆F₃N₃O₆
Molecular Weight:475.381
Hs Code.:

Synonyms:methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Chemical Property of methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

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Technology Process of methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

There total 7 articles about methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₄F₃N₃O₆

: 18107-18-1
diazomethyl-trimethyl-silane

: 1596367-77-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: With methanol; In diethyl ether; cyclohexane; at 0 ℃; for 0.5h;

Reference yield:

: 1403382-20-6
ethyl 2-[3-fluoro-2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596367-77-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

2: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water / 1,4-dioxane / 0.25 h / 85 °C

4: sodium hydride / mineral oil; N,N-dimethyl acetamide / 3 h / 20 - 110 °C / Inert atmosphere

5: methanol / cyclohexane; diethyl ether / 0.5 h / 0 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl acetamide; cyclohexane; mineral oil;

Reference yield:

: 866615-03-4
1-fluoro-2-(methoxymethoxy)-4-(trifluoro methyl)benzene

: 1596367-77-9
methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(4-nitro-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

3.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water / 1,4-dioxane / 0.25 h / 85 °C

5.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 3 h / 20 - 110 °C / Inert atmosphere

6.1: methanol / cyclohexane; diethyl ether / 0.5 h / 0 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium tert-butylate; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl acetamide; cyclohexane; mineral oil;