3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

Base Information

Chemical Name:3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid
CAS No.:152608-94-1
Molecular Formula:C₃₄H₃₅FO₆
Molecular Weight:558.647
Hs Code.:

Synonyms:3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

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Chemical Property of 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

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Technology Process of 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

There total 9 articles about 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 152608-90-7
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid ethyl ester

: 152608-94-1
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00022a006

Reference yield:

: 150-19-6
O-methylresorcine

: 152608-94-1
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pivalic acid / toluene / 16 h / Heating

2: 1 N HCl / tetrahydrofuran / 1 h

3: 44 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

4: 74 percent / aq. NaOH / methanol; tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; potassium carbonate; dimethyl sulfoxide; potassium iodide; Trimethylacetic acid; In tetrahydrofuran; methanol; toluene; butanone;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152608-94-1
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-6-methoxyphenyl>propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 44 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: 74 percent / aq. NaOH / methanol; tetrahydrofuran / 1 h / Ambient temperature

With triethylsilane; sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dimethyl sulfoxide; butanone; benzene;
DOI:10.1021/jm00022a006