carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

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Chemical Name:carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester
CAS No.:692753-24-5
Molecular Formula:C₄₉H₆₀FN₇O₈
Molecular Weight:894.056
Hs Code.:

carbonic acid <i>tert</i>-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1<i>H</i>-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3<i>H</i>-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

Synonyms:carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

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Chemical Property of carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

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Technology Process of carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

There total 8 articles about carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 692753-24-5
carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 46.0 g / p-dimethylaminopyridine / CH₂Cl₂ / 3.5 h / 20 °C

2: 77 percent / HF; pyridine / 4 h / 20 °C

3: 74 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 4 - 20 °C

4: K₂CO₃ / dimethylformamide / 5 h / 20 °C

5: dimethylformamide / 17 h / 20 °C

With pyridine; dmap; hydrogen fluoride; potassium carbonate; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2003.04.008

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 692753-24-5
carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / Cs₂CO₃ / dimethylformamide / 115 °C

2: tetrahydrofuran / 0.75 h / -70 - 20 °C

3: 46.0 g / p-dimethylaminopyridine / CH₂Cl₂ / 3.5 h / 20 °C

4: 77 percent / HF; pyridine / 4 h / 20 °C

5: 74 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 4 - 20 °C

6: K₂CO₃ / dimethylformamide / 5 h / 20 °C

7: dimethylformamide / 17 h / 20 °C

With pyridine; dmap; hydrogen fluoride; potassium carbonate; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2003.04.008

Reference yield:

: 692729-77-4
3-[4-(tert-butyl-dimethyl-silanyloxy)-butoxy]-benzaldehyde

: 692753-24-5
carbonic acid tert-butyl ester 1-(3-{3-[3-{1-[1-[1-butylcarbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-(1-methyl-1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl}-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-propoxy}-phenyl)-allyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 0.75 h / -70 - 20 °C

2: 46.0 g / p-dimethylaminopyridine / CH₂Cl₂ / 3.5 h / 20 °C

3: 77 percent / HF; pyridine / 4 h / 20 °C

4: 74 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 4 - 20 °C

5: K₂CO₃ / dimethylformamide / 5 h / 20 °C

6: dimethylformamide / 17 h / 20 °C

With pyridine; dmap; hydrogen fluoride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2003.04.008