1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine

Base Information

• Chemical Name: 1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine
• CAS No.: 891101-25-0
• Molecular Formula: C₁₉H₂₀N₂O₇
• Molecular Weight: 388.377
• Mol file: 891101-25-0.mol

Synonyms:1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine

Chemical Property of 1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine

There total 1 articles about 1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

thymin (65-71-4,28806-14-6,691841-57-3) + 1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-L-erythro-pentofuranose (170079-20-6) → 1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine (891101-25-0)

Guidance literature:

thymin; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; for 18h; Heating;

1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-L-erythro-pentofuranose; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1080/15257770008045443

Reference yield: 68.0%

1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine (891101-25-0) → 1-(5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1080/15257770008045443

Reference yield:

1-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-L-erythro-pentofuranosyl)thymine (891101-25-0) → 1-(5-O-benzoyl-2,2'-anhydro-3-deoxy-β-L-arabino-furanosyl)thymine

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / NaOMe / tetrahydrofuran / 2 h / 20 °C

2: 90 percent / PPh₃; DEAD / tetrahydrofuran / 0.25 h / 20 °C

With sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1080/15257770008045443

upstream raw materials:

thymin

1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-L-erythro-pentofuranose