(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Base Information

Chemical Name:(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
CAS No.:182618-48-0
Molecular Formula:C₄₈H₄₉N₃O₁₀
Molecular Weight:827.931
Hs Code.:

(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Synonyms:(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Suppliers and Price of (S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

There total 10 articles about (S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 182618-39-9
(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester

: 182618-48-0
(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1002/hlca.19960790602

Reference yield:

: 65729-90-0
1-chloro-N-acetyl-3,4,6-tri-O-benzyl-α-D-glucosamine

: 182618-48-0
(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Bu₃SnLi, 2.) BuLi / 1.) THF, -78 deg C, 1.5 h, 2.) THF/hexane, -78 deg C -> -65 deg C, 15 min

2: tetrahydrofuran / 1 h

3: 90 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 1-hydroxybenzotriazol, (i-Pr)2EtN / various solvent(s) / 1 h / Ambient temperature

4: 75 percent / CF₃COOH / CH₂Cl₂ / 2 h / Ambient temperature

With n-butyllithium; tri-n-butyltin lithium; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.19960790602

Reference yield:

: 7512-17-6,72-87-7,1136-42-1,1136-44-3,6082-29-7,6730-06-9,7772-94-3,10036-64-3,14131-60-3,14131-64-7,14131-68-1,14215-68-0,62057-49-2,62057-50-5,62057-51-6,62057-52-7,62057-53-8,62057-54-9,62057-55-0,62057-56-1,62075-50-7,62137-54-6,134451-97-1,134522-12-6,148347-16-4
N-Acetyl-D-glucosamine

: 182618-48-0
(S)-3-[((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: BF₃*Et₂O / 2 h / Heating

2: powdered KOH / dioxane / 4 h / Heating

3: 1.) KOt-Bu, 2.) 2M HCl / 1.) DMSO, 100 deg C, 3 h, 2.) acetone, reflux, 30 min

4: SOCl₂ / toluene; CHCl₃ / 0.5 h / 20 °C

5: 1.) Bu₃SnLi, 2.) BuLi / 1.) THF, -78 deg C, 1.5 h, 2.) THF/hexane, -78 deg C -> -65 deg C, 15 min

6: tetrahydrofuran / 1 h

7: 90 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 1-hydroxybenzotriazol, (i-Pr)2EtN / various solvent(s) / 1 h / Ambient temperature

8: 75 percent / CF₃COOH / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; n-butyllithium; thionyl chloride; tri-n-butyltin lithium; boron trifluoride diethyl etherate; potassium tert-butylate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; toluene;
DOI:10.1002/hlca.19960790602