dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

Base Information

Chemical Name:dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate
CAS No.:787629-77-0
Molecular Formula:C₂₁H₂₈NO₄P
Molecular Weight:389.431
Hs Code.:

Synonyms:dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

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Chemical Property of dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

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Technology Process of dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

There total 2 articles about dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 756-79-6
dimethyl methane phosphonate

: 609340-52-5
ethyl (S,S)-(-)-N,N-bis(α-methylbenzyl)glycinate

: 787629-77-0
dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 1.5h;

ethyl (S,S)-(-)-N,N-bis(α-methylbenzyl)glycinate; In tetrahydrofuran; hexane; at -78 ℃; for 4h;
DOI:10.1016/j.tetasy.2004.07.033

Reference yield:

: 21003-56-5,21003-57-6,23294-41-9,42287-48-9,56210-72-1,10024-74-5
(1S,1'S)-bis(1-phenylethyl)amine

: 787629-77-0
dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / Na₂CO₃; DMPU / 8 h / 95 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1.5 h / -50 °C

2.2: 87 percent / hexane; tetrahydrofuran / 4 h / -78 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sodium carbonate; In tetrahydrofuran; hexane;
DOI:10.1016/j.tetasy.2004.07.033

Reference yield:

: 787629-77-0
dimethyl (S,S)-(-)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate

: dimethyl 3-[(S,S)-N,N-bis(α-methylbenzylamino)]-(2R)-hydroxypropylphosphonate

: dimethyl 3-[(S,S)-N,N-bis(α-methylbenzylamino)]-(2S)-hydroxypropylphosphonate

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 4h; Further Variations:; Reagents; Solvents; Temperatures; Product distribution;
DOI:10.1016/j.tetasy.2004.07.033