(-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane

Base Information

• Chemical Name: (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane
• CAS No.: 148616-42-6
• Molecular Formula: C₁₁H₁₄ClO₃P
• Molecular Weight: 260.657
• Mol file: 148616-42-6.mol

Synonyms:(-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane

Chemical Property of (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane

There total 5 articles about (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,4R)-5,5-Dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide (161853-73-2) → (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane (148616-42-6)

Guidance literature:

With tetrachloromethane; triethylamine; In benzene; at 20 ℃; for 1h;

DOI:10.1021/ja992770k

Reference yield: 28.0%

(S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol (52178-66-2,98674-79-4) → (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane (148616-42-6)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; at -20 ℃; for 5h;

DOI:10.1021/ja992770k

Reference yield: 16.0%

(R)-(-)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide (98674-80-7) → (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane (148616-42-6)

Guidance literature:

With phosphorus pentachloride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ja992770k

upstream raw materials:

(2S,4R)-5,5-Dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide

(S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol

(R)-(-)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide

1-phenyl-2,2-dimethyl-1,3-propanediol