3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

Base Information

Chemical Name:3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide
CAS No.:1215011-53-2
Molecular Formula:C₂₅H₃₃N₅O₂S
Molecular Weight:467.635
Hs Code.:

Synonyms:3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

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Chemical Property of 3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

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Technology Process of 3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

There total 5 articles about 3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 109-01-3
1-methyl-piperazine

: 1215013-72-1
3'-formylbiphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

: 1215011-53-2
3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

Guidance literature:: With sodium tris(acetoxy)borohydride; In chloroform; at 50 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm500809c

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1215011-53-2
3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 24 h / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / chloroform / 24 h / 50 °C / Inert atmosphere

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium hydride; In chloroform; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1021/jm500809c

Reference yield:

: 28466-21-9
1,3,5-trimethyl-1H-pyrazol-4-amine

: 1215011-53-2
3'-(4-methylpiperazin-1-ylmethyl)-biphenyl-4-sulfonic acid methyl-(1,3,5-trimethyl-1H-pyrazol-4-yl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 24 h / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / chloroform / 24 h / 50 °C / Inert atmosphere

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium hydride; In chloroform; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1021/jm500809c