1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

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Chemical Name:1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol
CAS No.:1361190-12-6
Molecular Formula:C₁₉H₂₁BrN₄O₂
Molecular Weight:417.305
Hs Code.:

Synonyms:1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

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Chemical Property of 1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

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Technology Process of 1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

There total 5 articles about 1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 558-42-9
3-chloro-2-methylpropan-2-ol

: 1361189-68-5
3-[1-(4-bromophenyl)cyclobutyl]-5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazole

: 1361190-12-6
1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 40h; Inert atmosphere;
DOI:10.1021/jm501185j

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1361190-12-6
1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.33 h / 50 °C / Inert atmosphere

3.2: 4 h / 100 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 40 h / 90 °C / Inert atmosphere

With hydroxylamine; sodium hydride; potassium carbonate; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm501185j

Reference yield:

: 485828-58-8
1-(4- bromophenyl)cyclobutane-1-carbonitrile

: 1361190-12-6
1-(4-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.33 h / 50 °C / Inert atmosphere

2.2: 4 h / 100 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 40 h / 90 °C / Inert atmosphere

With hydroxylamine; potassium carbonate; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm501185j