(R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

Base Information

Chemical Name:(R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide
CAS No.:1613415-77-2
Molecular Formula:C₁₈H₂₁NO₅S
Molecular Weight:363.434
Hs Code.:

Synonyms:(R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

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Chemical Property of (R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

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Technology Process of (R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

There total 3 articles about (R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1613415-59-0
4-(2-(benzyloxy)ethyl)-5H-1,2,3-oxathiazole 2,2-dioxide

: 171364-79-7
2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1613415-77-2
(R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

Guidance literature:: With methanol; Rh⁽¹⁺⁾*HO^(1-)*C₂₀H₁₈; In 1,4-dioxane; at 80 ℃; for 48h; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol501464e

Reference yield:

: 185155-48-0
4-benzyloxy-1-hydroxybutan-2-one

: 1613415-77-2
(R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; sulphamoyl chloride / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: toluene-4-sulfonic acid / toluene / 2 h / Inert atmosphere; Schlenk technique; Reflux

3: Rh⁽¹⁺⁾*HO^(1-)*C₂₀H₁₈; methanol / 1,4-dioxane / 48 h / 80 °C / Schlenk technique; Inert atmosphere

With pyridine; methanol; Rh⁽¹⁺⁾*HO^(1-)*C₂₀H₁₈; sulphamoyl chloride; toluene-4-sulfonic acid; In 1,4-dioxane; toluene; acetonitrile;
DOI:10.1021/ol501464e

Reference yield:

: 1613415-84-1
C₁₁H₁₅NO₅S

: 1613415-77-2
(R)-4-(2-(benzyloxy)ethyl)-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 2 h / Inert atmosphere; Schlenk technique; Reflux

2: Rh⁽¹⁺⁾*HO^(1-)*C₂₀H₁₈; methanol / 1,4-dioxane / 48 h / 80 °C / Schlenk technique; Inert atmosphere

With methanol; Rh⁽¹⁺⁾*HO^(1-)*C₂₀H₁₈; toluene-4-sulfonic acid; In 1,4-dioxane; toluene;
DOI:10.1021/ol501464e