(1R,3R)-1-amino-3-methylcyclohexane

Base Information

• Chemical Name: (1R,3R)-1-amino-3-methylcyclohexane
• CAS No.: 64869-66-5
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.203
• Mol file: 64869-66-5.mol

Synonyms:(1R,3R)-1-amino-3-methylcyclohexane

Chemical Property of (1R,3R)-1-amino-3-methylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R)-1-amino-3-methylcyclohexane

There total 10 articles about (1R,3R)-1-amino-3-methylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methylcyclohexanone (591-24-2,625-96-7) → (1R,3R)-1-amino-3-methylcyclohexane (64869-66-5) + (1R,3S)-1-amino-3-methylcyclohexane (64869-65-4) + (1S,3R)-1-amino-3-methylcyclohexane (64869-63-2) + (1S,3S)-1-amino-3-methylcyclohexane (64869-64-3)

Guidance literature:

With glucose dehydrogenase; amine transaminase from Vibrio fluvialis; lactate dehydrogenase; In N,N-dimethyl-formamide; for 18h; Reagent/catalyst; Solvent; Time; Enzymatic reaction;

DOI:10.1002/cbic.201500074

Reference yield:

2-(trans-3-methylcyclohexyl)-1H-isoindole-1,3(2H)-dione → (1R,3R)-1-amino-3-methylcyclohexane (64869-66-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 85 ℃; for 3h;

DOI:10.1002/anie.202106716

Reference yield:

3-methylcyclohexen-2-one (1193-18-6) → (1R,3R)-1-amino-3-methylcyclohexane (64869-66-5)

Guidance literature:

With alpha-D-glucopyranose; glutamate dehydrogenase; L-alanin; recombinant double mutant enoate reductase YqjM Cys₂₆Asp/Ile₆₉Thr; recombinant mutant aminotransferase from Vibrio fluvialis Leu₅₆Ile; NADH; lactate dehydrogenase; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 89h; pH=7.5; Reagent/catalyst; diastereoselective reaction; Catalytic behavior; Enzymatic reaction;

DOI:10.1016/j.tet.2015.11.005

upstream raw materials:

(3R)-3-methylcyclohexanone

pulegone

5-methyl-5-hexen-1-al

3-Methylcyclohexanone

Downstream raw materials:

(1R)-trans-dimethylamino-1-methyl-cyclohexane

(1R)-trans-3-butyrylamino-1-methyl-cyclohexane

Refernces

• 1、 Bheemireddy, Narendraprasad Reddy,Biswas, Sovan,Evano, Gwilherm,Maes, Bert U. W.,Van Steijvoort, Ben F.,Waeterschoot, Marjo. "Expedient Synthesis of Bridged Bicyclic Nitrogen Scaffolds via Orthogonal Tandem Catalysis". supporting information. p. 21988 - 21996. Retrieved 2021/08/13.
• 2、 Demailly, Gilles,Solladie, Guy. "Biomimetic Polyene Cyclizations. Asymmetric Induction during the Acid-Catalyzed Cyclization of Chiral Imines". . p. 3102 - 3108. Retrieved 2007/10/02.