Hydroxyfasudil Hydrochloride

Base Information

• Chemical Name: Hydroxyfasudil Hydrochloride
• CAS No.: 155558-32-0
• Molecular Formula: C14H17 N3 O3 S . Cl H
• Molecular Weight: 343.82902
• European Community (EC) Number: 683-374-3
• DSSTox Substance ID: DTXSID20463911
• Mol file: 155558-32-0.mol

Synonyms:Hydroxyfasudil Hydrochloride;155558-32-0;HA 1100 hydrochloride;Hydroxyfasudil (hydrochloride);Hydroxy Fasudil Hydrochloride;Hydroxyfasudil HCl;HA-1100 hydrochloride;HA1100 hydrochloride;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one hydrochloride;5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one hydrochloride;1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1);5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride;Hydroxyfasudil (HA-1100) HCl;HA-1100*hydrochloride;HydroxyfasudilHydrochloride;C14H17N3O3S.HCl;Hydroxyfasudil monohydrochloride;SCHEMBL1845381;SCHEMBL16499912;DTXSID20463911;1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine Hydrochloride;BCP11069;FD5036;HB2293;HY-13911A;MFCD06411567;AKOS024457085;AKOS027250757;155558-32-0 (HCl salt);CS-1600;AC-35464;BS-15717;FT-0669631;H1745;A857915;SR-00000002171;J-009205;SR-00000002171-1;Hydroxyfasudil hydrochloride hydrate, >=98% (HPLC), solid;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride;1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride;5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one;hydrochloride;1-[(1,2-Dihydro-1-oxo-5-isoquinolin yl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

Chemical Property of Hydroxyfasudil Hydrochloride

Chemical Property:

• Melting Point: >250 (dec.)
• PSA: 90.91000
• LogP: 3.07390
• Storage Temp.: 2-8°C
• Solubility.: H2O: >5mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 343.0757403
• Heavy Atom Count: 22
• Complexity: 526

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy Fasudil Hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
• Uses: A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated ( ROCK) contraction both in vitro and in vivo. A A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.