acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Base Information

Chemical Name:acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester
CAS No.:280762-69-8
Molecular Formula:C₁₇H₁₈ClNO₃
Molecular Weight:319.788
Hs Code.:

Synonyms:acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Suppliers and Price of acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

There total 6 articles about acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 108-24-7
acetic anhydride

: 280762-68-7
[5-(benzyloxy)-4-(chloromethyl)-6-methyl-3-pyridinyl]methanol

: 280762-69-8
acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Guidance literature:: With pyridine; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(00)00121-6

Reference yield:

: 1136-52-3
(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

: 280762-69-8
acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / NaH / dimethylformamide / 15 h / 20 °C

2.1: 61 percent / pyridinium p-toluenesulfonate / ethanol / 20 h / Heating

3.1: NaOEt / ethanol / 0.33 h / -78 °C

3.2: 74 percent / xylene / 4 h / Heating

4.1: 98 percent / SOCl₂ / benzene / 0 °C / Heating

5.1: 82 percent / HCl / H₂O / 0.25 h / Heating

6.1: 48 percent / pyridine / 24 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; sodium ethanolate; pyridinium p-toluenesulfonate; sodium hydride; In ethanol; water; N,N-dimethyl-formamide; benzene; 1.1: Etherification / 2.1: Hydrolysis / 3.1: Substitution / 3.2: Etherification / 4.1: Substitution / 5.1: Hydrolysis / 6.1: Acetylation;
DOI:10.1016/S0040-4020(00)00121-6

Reference yield:

: 280762-56-3
4-(hydroxymethyl)-5-{[(4-methoxybenzyl)oxy]methyl}-2-methyl-3-pyridinol

: 280762-69-8
acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOEt / ethanol / 0.33 h / -78 °C

1.2: 74 percent / xylene / 4 h / Heating

2.1: 98 percent / SOCl₂ / benzene / 0 °C / Heating

3.1: 82 percent / HCl / H₂O / 0.25 h / Heating

4.1: 48 percent / pyridine / 24 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; sodium ethanolate; In ethanol; water; benzene; 1.1: Substitution / 1.2: Etherification / 2.1: Substitution / 3.1: Hydrolysis / 4.1: Acetylation;
DOI:10.1016/S0040-4020(00)00121-6