8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

Base Information

Chemical Name:8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid
CAS No.:1051391-37-7
Molecular Formula:C₄₂H₄₇N₅O₉S
Molecular Weight:797.929
Hs Code.:

8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

Synonyms:8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

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Chemical Property of 8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

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Technology Process of 8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

There total 8 articles about 8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1051391-41-3
(2S,4R)-2-{(1R,2S)-1-[2-(8-methoxycarbonyl-octanoylamino)-benzenesulfonylaminocarbonyl]-2-vinyl-cyclopropylcarbamoyl}-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1051391-37-7
8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

Guidance literature:: (2S,4R)-2-{(1R,2S)-1-[2-(8-methoxycarbonyl-octanoylamino)-benzenesulfonylaminocarbonyl]-2-vinyl-cyclopropylcarbamoyl}-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; at 20 ℃; for 1h;

With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; pH=5;

Reference yield:

: C₁₄H₁₉N₃O₃

: 1051391-37-7
8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.75 h / 20 °C

2.1: triethylamine / dmap / dichloromethane / 15 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 0 - 20 °C

5.1: trifluoroacetic acid / 1 h / 20 °C

5.2: 15 h / 20 °C

5.3: 20 °C / pH 5

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 2104-19-0
azelaic monomethyl ester

: 1051391-37-7
8-{2-[((1R,2S)-1-{[(2S,4R)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 1 h / 20 °C

2.1: triethylamine / dmap / dichloromethane / 15 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 0 - 20 °C

5.1: trifluoroacetic acid / 1 h / 20 °C

5.2: 15 h / 20 °C

5.3: 20 °C / pH 5

With hydrogenchloride; 1,2,3-Benzotriazole; thionyl chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; In 1,4-dioxane; dichloromethane;