5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 934178-96-8
• Molecular Formula: C₁₃H₁₀BrN₃O₂S
• Molecular Weight: 352.211
• Mol file: 934178-96-8.mol

Synonyms:5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

There total 4 articles about 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

p-toluenesulfonyl chloride (98-59-9) + 5-Bromopyrrolo<2,3-d>pyrimidine (175791-49-8) → 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (934178-96-8)

Guidance literature:

5-Bromopyrrolo<2,3-d>pyrimidine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

p-toluenesulfonyl chloride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

7H-pyrrolo[2,3-d]pyrimidine (271-70-5) → 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (934178-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: bromine / dichloromethane

With bromine; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.jmedchem.5b00301

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (934178-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: bromine / dichloromethane

With bromine; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.jmedchem.5b00301

upstream raw materials:

p-toluenesulfonyl chloride

5-Bromopyrrolo<2,3-d>pyrimidine

7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine