5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

Base Information

Chemical Name:5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole
CAS No.:1351159-16-4
Molecular Formula:C₁₈H₁₆F₄N₂O₂
Molecular Weight:368.331
Hs Code.:

Synonyms:5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

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Chemical Property of 5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

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Technology Process of 5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

There total 4 articles about 5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351158-96-7
(5-fluoro-1H-benzimidazol-2-yl)-(4-trifluoromethoxyphenyl)methanol

: 67-63-0,8013-70-5
isopropyl alcohol

: 1351159-16-4
5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

Guidance literature:: With sulfuric acid; at 140 - 160 ℃; for 3h; Microwave irradiation;

Reference yield:

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 1351159-16-4
5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 1.5 h / Cooling with ice; Reflux

2.1: benzenesulfonic acid / toluene / 40 h / Reflux

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 4 h / 20 °C / Cooling with ice

4.1: sulfuric acid / 3 h / 140 - 160 °C / Microwave irradiation

With hydrogenchloride; sulfuric acid; benzenesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; toluene;

Reference yield:

: 1977-72-6
5-fluoro-1H-benzoimidazole

: 1351159-16-4
5-fluoro-2-[isopropoxy(4-trifluoromethoxyphenyl)methyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzenesulfonic acid / toluene / 40 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / 20 °C / Cooling with ice

3.1: sulfuric acid / 3 h / 140 - 160 °C / Microwave irradiation

With sulfuric acid; benzenesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;