(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Base Information

Chemical Name:(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid
CAS No.:1541197-38-9
Molecular Formula:C₂₆H₂₉ClF₃N₅O₆
Molecular Weight:599.994
Hs Code.:

(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Synonyms:(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Chemical Property of (3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Technology Process of (3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

There total 12 articles about (3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541199-40-9
(3S)-ethyl 3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

: 1541197-38-9
(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In water; acetonitrile; at 20 ℃;

Reference yield:

: 1541198-39-3
C₁₁H₁₀ClF₃O

: 1541197-38-9
(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / ethanol / 7 h / 80 °C

2.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

2.2: 0.25 h / 20 °C

3.1: hydrogenchloride / 4 h / Reflux

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

4.2: 19 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; lithium hydroxide monohydrate; ammonium acetate; benzotriazol-1-ol; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1541198-37-1
C₁₀H₉BrClF₃O₃S

: 1541197-38-9
(3S)-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane; toluene / 8 h / -78 - 25 °C / Inert atmosphere

2.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / 80 °C

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

4.2: 0.25 h / 20 °C

5.1: hydrogenchloride / 4 h / Reflux

6.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

6.2: 19 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C

With hydrogenchloride; potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; lithium hydroxide monohydrate; ammonium acetate; benzotriazol-1-ol; sodium hydroxide; In ethanol; hexane; dichloromethane; di-isopropyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;