Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

Base Information

Chemical Name:Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat
CAS No.:127027-85-4
Molecular Formula:C₂₂H₂₀N₂O₅
Molecular Weight:392.411
Hs Code.:

Synonyms:Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

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Chemical Property of Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

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Technology Process of Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

There total 5 articles about Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 108-05-4,9003-20-7
vinyl acetate

: 127027-84-3
Methyl-6-(benzyloxy)-5-(N-hydroxyacetamido)-7-methoxyindol-2-carboxylat

: 127027-85-4
Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

Guidance literature:: With lithium tetrachloropalladate(II); In dimethyl sulfoxide; at 55 ℃; for 5h;
DOI:10.1002/hlca.19890720717

Reference yield:

: 127027-75-2
Methyl-6-(benzyloxy)-2,3-dihydro-7-methoxyindol-2-carboxylat

: 127027-85-4
Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / Et₃N / acetonitrile / 8 h / 60 °C

2: 1.) 100 percent HNO₃, Ac₂O, 2.) Et₃N / 1.) room temperature, 1 h, 2.) MeCN, 8 h, room temperature

3: hydrogen, conc. NH₄OH, DMSO / 5 percent Pd/C / tetrahydrofuran / 2.75 h / 15 °C

4: NaHCO₃ / H₂O; tetrahydrofuran / 2 h / 5 °C

5: 33 percent / Li₂PdCl₄ / dimethylsulfoxide / 5 h / 55 °C

With ammonium hydroxide; lithium tetrachloropalladate(II); hydrogen; nitric acid; acetic anhydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/hlca.19890720717

Reference yield:

: 127027-80-9
Methyl-6-(benzyloxy)-7-methoxy-5-nitroindol-2-carboxylat

: 127027-85-4
Methyl-6-acetyl-5-(benzyloxy)-4-methoxypyrrolo<3,2-e>indol-2-carboxylat

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen, conc. NH₄OH, DMSO / 5 percent Pd/C / tetrahydrofuran / 2.75 h / 15 °C

2: NaHCO₃ / H₂O; tetrahydrofuran / 2 h / 5 °C

3: 33 percent / Li₂PdCl₄ / dimethylsulfoxide / 5 h / 55 °C

With ammonium hydroxide; lithium tetrachloropalladate(II); hydrogen; sodium hydrogencarbonate; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1002/hlca.19890720717