N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

Base Information

Chemical Name:N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine
CAS No.:858104-62-8
Molecular Formula:C₂₈H₂₆F₂N₂O₆S
Molecular Weight:556.587
Hs Code.:

Synonyms:N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

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Chemical Property of N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

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Technology Process of N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

There total 8 articles about N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 858103-90-9
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

: 858104-62-8
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

Guidance literature:: N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine; With sodium tetrahydroborate; In methanol; for 0.5h;

With ammonium acetate; water; In methanol;

Reference yield:

: 858104-49-1
(3R,4R)-1-(4-fluorophenyl)-3-[(4-fluorobenzoyl)methylthio]-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one

: 858104-62-8
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.1: 4-methyl-morpholine / dichloromethane / 0.08 h / 20 °C

2.2: 2 h

2.3: 1.5 h

3.1: sodium tetrahydroborate / methanol / 0.5 h

With 4-methyl-morpholine; sodium tetrahydroborate; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

: 858104-44-6
tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate

: 858104-62-8
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-D-alanine

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.08 h / 0 °C

1.2: 0.33 h / -40 - 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C

2.2: 18 h / 45 °C

2.3: 6 h / 45 °C

3.1: dichloromethane / 2 h / 0 °C

4.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

6.1: 4-methyl-morpholine / dichloromethane / 0.08 h / 20 °C

6.2: 2 h

6.3: 1.5 h

7.1: sodium tetrahydroborate / methanol / 0.5 h

With 4-methyl-morpholine; titanium(IV) isopropylate; sodium tetrahydroborate; tributylphosphine; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; trifluoroacetic acid; In methanol; dichloromethane; acetone; toluene;