(2R,5R)-2,5-Diphenylpyrrolidine

Base Information

• Chemical Name: (2R,5R)-2,5-Diphenylpyrrolidine
• CAS No.: 155155-73-0
• Molecular Formula: C16H17 N
• Molecular Weight: 223.318
• Hs Code.: 2933990090
• European Community (EC) Number: 680-171-1
• DSSTox Substance ID: DTXSID70450119
• Nikkaji Number: J1.383.967K
• Wikidata: Q76416341
• Mol file: 155155-73-0.mol

Synonyms:(2R,5R)-2,5-Diphenylpyrrolidine;155155-73-0;Pyrrolidine, 2,5-diphenyl-, (2R,5R)-;(2R,5R)-Diphenylpyrrolidine;rel-(2R,5R)-2,5-Diphenylpyrrolidine;22147-84-8;SCHEMBL1763221;2beta,5alpha-Diphenylpyrrolidine;DTXSID70450119;(+)-trans-2,5-diphenylpyrrolidine;AKOS015840426;CS-W013086;BS-43895;D3185;D90150

Chemical Property of (2R,5R)-2,5-Diphenylpyrrolidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 50 °C
• Refractive Index: 109 ° (C=1, CHCl3)
• Boiling Point: 356.13°C at 760 mmHg
• PKA: 9.76±0.10(Predicted)
• Flash Point: 110 °C
• PSA: 12.03000
• Density: 1.048g/cm³
• LogP: 4.18120
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: soluble in Chloroform
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 223.136099547
• Heavy Atom Count: 17
• Complexity: 202

Purity/Quality:

97% ^*data from raw suppliers

(2R,5R)-2,5-Diphenylpyrrolidine >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 40-50/53
• Safety Statements: 23-24/25-36/37-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1C2=CC=CC=C2)C3=CC=CC=C3
• Isomeric SMILES: C1C[C@@H](N[C@H]1C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of (2R,5R)-2,5-Diphenylpyrrolidine

There total 16 articles about (2R,5R)-2,5-Diphenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R,R)-N-allyl-trans-2,5-diphenylpyrrolidine → (R,R)-2,5-diphenylpyrrolidine (155155-73-0)

Guidance literature:

With Wilkinson's catalyst; In water; acetonitrile; for 3h; Heating;

DOI:10.1016/0957-4166(95)00026-L

Reference yield: 71.0%

(2S,5S)-N-allyl-2,5-diphenylpyrrolidine (295328-86-8) → (R,R)-2,5-diphenylpyrrolidine (155155-73-0)

Guidance literature:

With tris-triphenylphosphine ruthenium(II) chloride; In water; acetonitrile;

DOI:10.1016/j.tetlet.2015.01.140

Reference yield: 66.0%

C30H30N2O3S2 → (R,R)-2,5-diphenylpyrrolidine (155155-73-0)

Guidance literature:

With methanol; magnesium; at 20 ℃; for 2h; Sonication;

DOI:10.1002/anie.202107898

upstream raw materials:

(2R,5R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,5-bisphenylpyrrolidine

1-amino-2-propene

(2S,5S)-N-allyl-2,5-diphenylpyrrolidine

phenacylacetophenone

Downstream raw materials:

4-[2,5-(R,R)-diphenyl-pyrrolidin-1-yl]-3-butene-2-one

(R,R)-2,5-diphenyl-1-acryloylpyrrolidine

1-((2R,5R)-2,5-Diphenyl-pyrrolidin-1-yl)-2-phenyl-ethanone