(E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol

Base Information

• Chemical Name: (E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol
• CAS No.: 1375090-56-4
• Molecular Formula: C₁₆H₁₈N₄O₄
• Molecular Weight: 330.343
• Mol file: 1375090-56-4.mol

Synonyms:(E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol

Chemical Property of (E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol

There total 2 articles about (E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(E)-1-(4-nitrophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol (1375090-55-3) → (E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol (1375090-56-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 3.5h;

DOI:10.1016/j.bmcl.2012.03.028

Reference yield:

C15H18N4O3 (76714-97-1) → (E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol (1375090-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 4.5 h / 0 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3.5 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.028

Reference yield: 3.0%

(E)-6-tert-butyl-5-(4-nitrobenzylidene)-6,8-dihydro-5H-[1,2,4]triazolo[5,1-c][1,4]oxazin-8-ol (1375090-56-4) → C16H18N4O3 (1375090-52-0)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 408h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.03.028

upstream raw materials:

C₁₅H₁₈N₄O₃

(E)-1-(4-nitrophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol

Downstream raw materials:

C₁₆H₁₈N₄O₃