(S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester

Base Information

• Chemical Name: (S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester
• CAS No.: 216880-29-4
• Molecular Formula: C₂₂H₂₆N₂O₆
• Molecular Weight: 414.458
• Mol file: 216880-29-4.mol

Synonyms:(S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester

Chemical Property of (S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester

There total 1 articles about (S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate (24498-31-5) + 4-hydroxy-benzoic acid (99-96-7) → (S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester (216880-29-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1021/ja980810z

Reference yield: 86.0%

(S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester (216880-29-4) → (S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid (216880-30-7)

Guidance literature:

With sodium hydroxide; In methanol; at 5 ℃; for 2.5h;

DOI:10.1021/ja980810z

Reference yield:

(S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid methyl ester (216880-29-4) → [(S)-5-(4-Hydroxy-benzoylamino)-5-(4-hydroxy-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester (216880-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / aq. NaOH / methanol / 2.5 h / 5 °C

2: DCC / tetrahydrofuran / 4 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;

DOI:10.1021/ja980810z

upstream raw materials:

(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate

4-hydroxy-benzoic acid

Downstream raw materials:

(S)-6-Benzyloxycarbonylamino-2-(4-hydroxy-benzoylamino)-hexanoic acid

[(S)-5-(4-Hydroxy-benzoylamino)-5-(4-hydroxy-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester

{(S)-5-[4-(Bis-benzyloxy-phosphoryloxy)-benzoylamino]-5-[4-(bis-benzyloxy-phosphoryloxy)-phenylcarbamoyl]-pentyl}-carbamic acid benzyl ester