3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

Base Information

Chemical Name:3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester
CAS No.:1387641-12-4
Molecular Formula:C₂₅H₂₈N₂O₈
Molecular Weight:484.506
Hs Code.:

Synonyms:3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

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Chemical Property of 3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

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Technology Process of 3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

There total 6 articles about 3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1387641-66-8
6,7-bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid

: 1387641-12-4
3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1387641-12-4
3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 14 h / 85 °C

2.1: nitric acid / acetic acid / 1 h / 4 °C

2.2: 4 - 20 °C

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 2 h / 1551.49 Torr

4.1: piperidine / acetic acid / methanol / 18 h / 65 °C

5.1: sodium hydroxide; water / methanol / 2 h / 60 °C

5.2: Cooling

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With piperidine; water; hydrogen; nitric acid; potassium carbonate; triethylamine; HATU; sodium hydroxide; palladium on activated charcoal; acetic acid; potassium iodide; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 80407-64-3
3,4-bis(2-methoxyethoxy)benzaldehyde

: 1387641-12-4
3-{[6,7-Bis-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid / acetic acid / 1 h / 4 °C

1.2: 4 - 20 °C

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 2 h / 1551.49 Torr

3.1: piperidine / acetic acid / methanol / 18 h / 65 °C

4.1: sodium hydroxide; water / methanol / 2 h / 60 °C

4.2: Cooling

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With piperidine; water; hydrogen; nitric acid; triethylamine; HATU; sodium hydroxide; palladium on activated charcoal; acetic acid; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;