1-Benzyl-4,4-difluoropiperidine

Base Information

Chemical Name:1-Benzyl-4,4-difluoropiperidine
CAS No.:155137-18-1
Molecular Formula:C12H15 F2 N
Molecular Weight:211.255
Hs Code.:2933399090
European Community (EC) Number:672-533-2
DSSTox Substance ID:DTXSID60382314
Wikidata:Q82173639
Mol file:155137-18-1.mol

Synonyms:1-benzyl-4,4-difluoropiperidine;155137-18-1;MFCD03840201;SCHEMBL2918565;N-benzyl-4,4-difluoropiperidine;AMY7066;DTXSID60382314;AKOS005254434;CS-W015052;PS-6461;SB43373;s11972;FT-0741657;Piperidine, 4,4-difluoro-1-(phenylmethyl)-;EN300-329673;A809613

Suppliers and Price of 1-Benzyl-4,4-difluoropiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-benzyl-4,4-difluoropiperidine
10mg
$ 45.00

TRC
1-benzyl-4,4-difluoropiperidine
50mg
$ 60.00

Matrix Scientific
1-Benzyl-4,4-difluoropiperidine
5g
$ 48.00

Matrix Scientific
1-Benzyl-4,4-difluoropiperidine
25g
$ 178.00

JR MediChem
4,4-Difluoro-1-(phenylmethyl)piperidine 98%
25g
$ 198.00

JR MediChem
4,4-Difluoro-1-(phenylmethyl)piperidine 98%
1kg
$ 4980.00

JR MediChem
4,4-Difluoro-1-(phenylmethyl)piperidine 98%
100g
$ 598.00

Crysdot
1-Benzyl-4,4-difluoropiperidine 95+%
100g
$ 446.00

Chemenu
1-Benzyl-4,4-difluoropiperidine 95%
100g
$ 421.00

Apolloscientific
1-Benzyl-4,4-difluoropiperidine
100mg
$ 10.00

Total 19 raw suppliers

Chemical Property of 1-Benzyl-4,4-difluoropiperidine

Chemical Property:

Refractive Index:1.4975
Boiling Point:74-79ºC/0.1mm
Flash Point:74-79°C/0.1mm
PSA：3.24000
LogP:2.85560
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:211.11725581
Heavy Atom Count:15
Complexity:190

Purity/Quality:

97% ^*data from raw suppliers

1-benzyl-4,4-difluoropiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1(F)F)CC2=CC=CC=C2

Technology Process of 1-Benzyl-4,4-difluoropiperidine

There total 2 articles about 1-Benzyl-4,4-difluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 155137-18-1
1-benzyl-4,4-difluoropiperidine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1448295-70-2
1-benzyl-4-fluoro-1,2,3,6-tetrahydropyridine

: 155137-18-1
1-benzyl-4,4-difluoropiperidine

Guidance literature:: With triethylamine tris(hydrogen fluoride); triethylamine; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In N,N-dimethyl acetamide; at 20 ℃; for 16h; Overall yield = 14 %; Overall yield = 18 mg; Inert atmosphere;
DOI:10.1021/acs.orglett.7b01581