Technology Process of 2-<4-(4-benzhydryl-1-piperidinyl)phenyl>ethyl alcohol
There total 10 articles about 2-<4-(4-benzhydryl-1-piperidinyl)phenyl>ethyl alcohol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
for 1h;
Ambient temperature;
DOI:10.1248/cpb.39.91
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 81 percent / pyridine / 17 h / Ambient temperature
2: 45 percent / various solvent(s); 2-methyl-propan-2-ol / 15 h / 80 - 90 °C
3: K2CO3 / methanol / 1 h / Ambient temperature
4: pTsOH, molecular sieves 3 A / CH2Cl2 / 1.5 h / Ambient temperature
5: 2) 12N H2SO4 / 1) Et2O, r.t, 1.5h
6: 96 percent / diethyl ether; tetrahydrofuran / 0.67 h
7: 66 percent / 2:8 H2SO4-AcOH / 1 h / Ambient temperature
8: 79 percent / H2 / 10percent Pd-C / acetic acid; aq. HClO4 / 3 h / 65 - 70 °C
9: 91 percent / K2CO3 / methanol / 1 h / Ambient temperature
With
pyridine; 3 A molecular sieve; sulfuric acid; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; perchloric acid; diethyl ether; dichloromethane; acetic acid; tert-butyl alcohol;
DOI:10.1248/cpb.39.91
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 96 percent / NaBH4 / methanol / 0.5 h / 0 °C
2: 81 percent / pyridine / 17 h / Ambient temperature
3: 45 percent / various solvent(s); 2-methyl-propan-2-ol / 15 h / 80 - 90 °C
4: K2CO3 / methanol / 1 h / Ambient temperature
5: pTsOH, molecular sieves 3 A / CH2Cl2 / 1.5 h / Ambient temperature
6: 2) 12N H2SO4 / 1) Et2O, r.t, 1.5h
7: 96 percent / diethyl ether; tetrahydrofuran / 0.67 h
8: 66 percent / 2:8 H2SO4-AcOH / 1 h / Ambient temperature
9: 79 percent / H2 / 10percent Pd-C / acetic acid; aq. HClO4 / 3 h / 65 - 70 °C
10: 91 percent / K2CO3 / methanol / 1 h / Ambient temperature
With
pyridine; sodium tetrahydroborate; 3 A molecular sieve; sulfuric acid; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; perchloric acid; diethyl ether; dichloromethane; acetic acid; tert-butyl alcohol;
DOI:10.1248/cpb.39.91
