1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone

Base Information

• Chemical Name: 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone
• CAS No.: 19349-26-9
• Molecular Formula: C₂₁H₁₈ClNO₂
• Molecular Weight: 351.832
• Mol file: 19349-26-9.mol

Synonyms:1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone

Chemical Property of 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone

There total 6 articles about 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(4-chlorophenyl)-2-(4-methoxyphenylimino)-2-phenylethanone → 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone (19349-26-9)

Guidance literature:

With 2-picoline borane complex; phenylphosphinic acid; In methanol; dichloromethane; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2018.03.048

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone (19349-26-9)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

2: tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

4: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

5: 2-picoline borane complex; phenylphosphinic acid / dichloromethane; methanol / 20 °C / Inert atmosphere

With 2-picoline borane complex; phenylphosphinic acid; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tet.2018.03.048

Reference yield:

C12H13ClN2O → 1-(4-chlorophenyl)-2-(4-methoxyphenylamino)-2-phenylethanone (19349-26-9)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

2: tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

4: 2-picoline borane complex; phenylphosphinic acid / dichloromethane; methanol / 20 °C / Inert atmosphere

With 2-picoline borane complex; phenylphosphinic acid; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tet.2018.03.048

upstream raw materials:

4-chlorobenzaldehyde