(2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

Base Information

Chemical Name:(2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid
CAS No.:550356-41-7
Molecular Formula:C₂₅H₃₁Cl₃N₂O₉
Molecular Weight:609.888
Hs Code.:

Synonyms:(2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

There total 10 articles about (2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 550356-41-7
(2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃

2: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

3: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

4: 83 percent / K₂CO₃ / dimethylformamide / 20 °C

5: 26 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

6: H₂O / 11688 h / 20 °C

With pyridine; water; hydrogen; potassium carbonate; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 550356-41-7
(2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2 / dimethylformamide

2: K₂CO₃

3: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

4: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

5: 83 percent / K₂CO₃ / dimethylformamide / 20 °C

6: 26 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

7: H₂O / 11688 h / 20 °C

With pyridine; oxalyl dichloride; water; hydrogen; potassium carbonate; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p

Reference yield:

: 260391-49-9
(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(2-(hydroxymethyl)pyrrolidin-1-yl)methanone

: 550356-41-7
(2S)-1-(2-{[(allyloxy)carbonyl]amino}-5-methoxy-4-{[6-oxo-6-(2,2,2-trichloroethoxy)hexyl]oxy}benzoyl)-2-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

2: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

3: 83 percent / K₂CO₃ / dimethylformamide / 20 °C

4: 26 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

5: H₂O / 11688 h / 20 °C

With pyridine; water; hydrogen; potassium carbonate; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p