6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

Base Information

Chemical Name:6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine
CAS No.:1198109-88-4
Molecular Formula:C₁₅H₁₃ClF₂N₄O₂
Molecular Weight:354.744
Hs Code.:

Synonyms:6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

Suppliers and Price of 6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

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Chemical Property of 6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

Chemical Property:

Purity/Quality:

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Technology Process of 6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

There total 3 articles about 6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(difluoromethoxy)-2-methoxy-5-nitrobenzene

: 1198109-88-4
6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

: C₁₆H₁₇ClF₂N₄O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; ammonium chloride / industrial methylated spirits; water / 2 h / 75 °C

2.1: hydrogenchloride / industrial methylated spirits; water / 16 h / 85 °C

2.2: pH 12

3.1: acetic acid / acetonitrile / 17 h / Reflux

With hydrogenchloride; iron; ammonium chloride; acetic acid; In industrial methylated spirits; water; acetonitrile;

Reference yield:

: 97963-82-1
3-(difluoromethoxy)-4-methoxyaniline

: 1198109-88-4
6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

: C₁₆H₁₇ClF₂N₄O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / industrial methylated spirits; water / 16 h / 85 °C

1.2: pH 12

2.1: acetic acid / acetonitrile / 17 h / Reflux

With hydrogenchloride; acetic acid; In industrial methylated spirits; water; acetonitrile;

Reference yield:

: 636-93-1
5-nitroguaiacol

: 1198109-88-4
6-chloro-9-(3-(difluoromethoxy)-4-methoxyphenyl)-2,8-dimethyl-9H-purine

: C₁₆H₁₇ClF₂N₄O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / water; N,N-dimethyl-formamide / 62 h / 20 - 80 °C / Inert atmosphere

2.1: iron; ammonium chloride / industrial methylated spirits; water / 2 h / 75 °C

3.1: hydrogenchloride / industrial methylated spirits; water / 16 h / 85 °C

3.2: pH 12

4.1: acetic acid / acetonitrile / 17 h / Reflux

With hydrogenchloride; iron; ammonium chloride; caesium carbonate; acetic acid; In industrial methylated spirits; water; N,N-dimethyl-formamide; acetonitrile;