6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Base Information

Chemical Name:6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride
CAS No.:1021910-71-3
Molecular Formula:C₁₁H₁₃N₃O₂*ClH
Molecular Weight:255.704
Hs Code.:

Synonyms:6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Suppliers and Price of 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

There total 8 articles about 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1021910-14-4
6-amino-5,6-dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione hydrochloride

: 1021910-71-3,92260-83-8
6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Guidance literature:: 6-amino-5,6-dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione hydrochloride; With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; for 18h;

With hydrogenchloride; In methanol; water;

Reference yield:

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one: 52099-72-6
1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

: 1021910-71-3,92260-83-8
6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 18 h / Heating / reflux

2.1: sodium hydroxide; water / tetrahydrofuran / 20 °C / Heating / reflux

2.2: 0.5 h / 2 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h

4.1: thionyl chloride / dichloromethane / 2 h / 20 °C

4.2: 20 °C / Heating / reflux

5.1: hydrogenchloride; t-butylnitrite; acetic acid / 1,4-dioxane / 3 h / 20 °C

6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 1137.76 Torr

7.1: sodium tetrahydroborate / methanol / 18.5 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; t-butylnitrite; water; hydrogen; potassium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetone;

Reference yield:

: 92260-82-7
4,5,6,7-tetrahydro-6-hydroxyimino-imidazo[4,5,1-jk]-[1]-benzazepine-2,7(1H,6H)-dione

: 1021910-71-3,92260-83-8
6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 1137.76 Torr

2: sodium tetrahydroborate / methanol / 18.5 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium 10% on activated carbon; In methanol;