3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one

Base Information

• Chemical Name: 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one
• CAS No.: 241161-64-8
• Molecular Formula: C₁₃H₁₀N₆O
• Molecular Weight: 266.262

Synonyms:3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one

Chemical Property of 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one

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Technology Process of 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one

There total 8 articles about 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N'-(4-methyl-benzylidene)-hydrazine (246855-12-9) → 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one (241161-64-8)

Guidance literature:

With nitric acid; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1039/a903676h

Reference yield: 60.0%

4-[N'-(4-methyl-benzylidene)-hydrazino]-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one (224577-55-3) → 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one (241161-64-8)

Guidance literature:

With water; nitric acid; In N,N-dimethyl-formamide; at 100 ℃; for 9h;

DOI:10.1039/a907673e

Reference yield:

2,4,6-trichloropyrimidine-5-carbaldehyde (50270-27-4) → 3-p-tolyl-6,7-dihydro-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-5-one (241161-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / NH₂NH₂ / 2-methoxy-ethanol / 0.5 h / 0 °C

2: 78 percent / dimethylformamide / 10 h / 20 °C

3: 67 percent / HNO₃; H₂O / dimethylformamide / 3 h / 100 °C

With water; nitric acid; hydrazine; In 2-methoxy-ethanol; N,N-dimethyl-formamide; 1: Substitution / 2: Condensation / 3: Cyclization;

DOI:10.1039/a907673e

upstream raw materials:

N-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N'-(4-methyl-benzylidene)-hydrazine

4-[N'-(4-methyl-benzylidene)-hydrazino]-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one

oxypurinol

4,5-Dihydro-4-thioxo-1H-pyrazolo[3,4-d]pyrimidin-6(7H)-one

Downstream raw materials:

5-chloro-3-p-tolyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine

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