1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Base Information

Chemical Name:1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride
CAS No.:63125-28-0
Molecular Formula:C₁₈H₂₀BrNO₄*ClH
Molecular Weight:430.726
Hs Code.:

Synonyms:1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Suppliers and Price of 1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

There total 4 articles about 1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 72264-51-8,75879-36-6,75879-37-7
(+/-)-6'-Bromo-N-formyl-N-norreticuline

: 63125-28-0
1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 24h; Heating;
DOI:10.1021/jo01292a008

Reference yield:

: 72258-92-5
(+/-)-N-Formyl-N-norreticuline

: 63125-28-0
1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Br₂ / acetic acid

2: 90 percent / aqueous HCl / methanol / 24 h / Heating

With hydrogenchloride; bromine; In methanol; acetic acid;
DOI:10.1021/jo01292a008

Reference yield:

: 72258-86-7
(+/-)-N-Norreticuline Tosylate Salt

: 63125-28-0
1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / sodium methoxide / dimethylformamide / 48 h / Heating

2: 90 percent / Br₂ / acetic acid

3: 90 percent / aqueous HCl / methanol / 24 h / Heating

With hydrogenchloride; bromine; sodium methylate; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo01292a008