N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine

Base Information

• Chemical Name: N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine
• CAS No.: 126049-66-9
• Molecular Formula: C₂₇H₃₁N₃O₄Si
• Molecular Weight: 489.646

Synonyms:N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine

Chemical Property of N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine

There total 6 articles about N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-{1-[(2R,3R,5S)-3-Benzenesulfinyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-acetamide (132336-23-3) → N4-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine (126049-66-9)

Guidance literature:

With tributyl-amine; In xylene; for 1.5h; Heating; or DBU;

DOI:10.1246/cl.1990.1459

Reference yield:

(5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one (102717-29-3) → N4-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine (126049-66-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) lithium cyclohexylisopropylamide (LCIA) / THF, -20 deg C

2: DIBAL-H / tetrahydrofuran / -78 °C

3: 69 percent / DMAP / CH₂Cl₂

4: 93 percent / SnCl₄ / 1,2-dichloro-ethane / 4 h / 0 °C

5: mCPBA / CH₂Cl₂ / 3 h / 0 °C

6: 56 percent / tributylamine / xylene / 1.5 h / Heating; or DBU

With dmap; tributyl-amine; diisobutylaluminium hydride; lithium cyclohexylisopropylamide; 3-chloro-benzenecarboperoxoic acid; tin(IV) chloride; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; xylene;

DOI:10.1246/cl.1990.1459

Reference yield:

(3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-phenylsulfanyl-tetrahydro-furan-2-ol (142495-48-5) → N4-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine (126049-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / DMAP / CH₂Cl₂

2: 93 percent / SnCl₄ / 1,2-dichloro-ethane / 4 h / 0 °C

3: mCPBA / CH₂Cl₂ / 3 h / 0 °C

4: 56 percent / tributylamine / xylene / 1.5 h / Heating; or DBU

With dmap; tributyl-amine; 3-chloro-benzenecarboperoxoic acid; tin(IV) chloride; In dichloromethane; 1,2-dichloro-ethane; xylene;

DOI:10.1246/cl.1990.1459

upstream raw materials:

N-{1-[(2R,3R,5S)-3-Benzenesulfinyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-acetamide

N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-phenylthio-β-D-erythro-pentofuranosyl>cytosine

N⁴-acetyl-O-trimethylsilylcytosine

(3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-phenylsulfanyl-tetrahydro-furan-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 126049-66-9 N⁴-acetyl-1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl>cytosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send