erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

Base Information

Chemical Name:erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride
CAS No.:120578-79-2
Molecular Formula:C₂₂H₃₀ClNO₂*ClH
Molecular Weight:412.4
Hs Code.:

Synonyms:erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

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Chemical Property of erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

Chemical Property:

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Technology Process of erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

There total 6 articles about erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 120578-77-0
erythro-5,6-bis(4-hydroxyphenyl)-N-(2-hydroxyethyl)-1-octylamine

: 120578-79-2
erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

Guidance literature:: With thionyl chloride; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00127a023

Reference yield:

: tert-butyl 6-hydroxy-5,6-bis(4-methoxyphenyl)octanoate

: 120578-79-2
erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 45.5 percent / H₂, perchloric acid / Pd/C / acetic acid / 2250.2 Torr

2: 90 percent / dicyclohexyl carbodiimide / tetrahydrofuran

3: 77 percent / tetrahydrofuran

4: 46 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / Ambient temperature

5: 54 percent / BBr₃ / CH₂Cl₂

6: 75 percent / thionyl chloride / CH₂Cl₂ / 3 h / Ambient temperature

With lithium aluminium tetrahydride; thionyl chloride; perchloric acid; hydrogen; boron tribromide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00127a023

Reference yield:

: 107036-38-4,120578-47-4,120578-48-5
(5S*,6R*)-5,6-bis(4-methoxyphenyl)-1-octanoic acid

: 120578-79-2
erythro-5,6-bis(4-hydroxyphenyl)-N-(2-chloroethyl)-1-octylamine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / dicyclohexyl carbodiimide / tetrahydrofuran

2: 77 percent / tetrahydrofuran

3: 46 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / Ambient temperature

4: 54 percent / BBr₃ / CH₂Cl₂

5: 75 percent / thionyl chloride / CH₂Cl₂ / 3 h / Ambient temperature

With lithium aluminium tetrahydride; thionyl chloride; boron tribromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00127a023