C₂₂H₁₇F₃N₄O

Base Information

• Chemical Name: C₂₂H₁₇F₃N₄O
• CAS No.: 1352338-63-6
• Molecular Formula: C₂₂H₁₇F₃N₄O
• Molecular Weight: 410.398
• Mol file: 1352338-63-6.mol

Synonyms:C₂₂H₁₇F₃N₄O

Chemical Property of C₂₂H₁₇F₃N₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₁₇F₃N₄O

There total 11 articles about C₂₂H₁₇F₃N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C15H14F3N3O (1352342-56-3) + phenyl isothiocyanate (103-72-0) → C22H17F3N4O (1352338-63-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 80 ℃;

Reference yield:

4-amino-3-(trifluoromethyl)-phenol (445-04-5) → C22H17F3N4O (1352338-63-6)

Guidance literature:

Multi-step reaction with 11 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

2.1: methanol / 3 h / Reflux

3.1: diphenylether / 1.17 h / 200 - 250 °C

4.1: 2,6-dimethylpyridine / dmap / dichloromethane / 1 h / 0 - 20 °C

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 105 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 7.5 h

7.1: 2,6-dimethylpyridine / dmap / dichloromethane / 1.5 h / 0 - 20 °C

8.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 105 °C

9.1: potassium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine; t-butoxycarbonylhydrazine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

10.2: 0.5 h

11.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 80 °C

With 2,6-dimethylpyridine; t-butoxycarbonylhydrazine; di-isopropyl azodicarboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

C22H22F3NO5 → C22H17F3N4O (1352338-63-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: diphenylether / 1.17 h / 200 - 250 °C

2.1: 2,6-dimethylpyridine / dmap / dichloromethane / 1 h / 0 - 20 °C

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 105 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 7.5 h

5.1: 2,6-dimethylpyridine / dmap / dichloromethane / 1.5 h / 0 - 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 105 °C

7.1: potassium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; t-butoxycarbonylhydrazine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

8.2: 0.5 h

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,2-dichloro-ethane / 80 °C

With 2,6-dimethylpyridine; t-butoxycarbonylhydrazine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

C₁₅H₁₄F₃N₃O

phenyl isothiocyanate

4-amino-3-(trifluoromethyl)-phenol

4-(benzyloxy)-2-(trifluoromethyl)aniline