12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one

Base Information

• Chemical Name: 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one
• CAS No.: 328934-28-7
• Molecular Formula: C₇₄H₁₃₀N₆O₁₄
• Molecular Weight: 1327.88
• Mol file: 328934-28-7.mol

Synonyms:12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one

Chemical Property of 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one

There total 8 articles about 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (23978-55-4) + 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl chloride → 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one (328934-28-7)

Guidance literature:

With dmap; triethylamine; for 48h;

DOI:10.1039/b005436o

Reference yield: 59.0%

7-benzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (94605-71-7) + 12-Bromo-1-[16-(12-bromo-dodecanoyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl]-dodecan-1-one (165191-86-6) → 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one (328934-28-7)

Guidance literature:

With sodium carbonate; potassium iodide; In various solvent(s); for 48h; Heating;

DOI:10.1002/jhet.5570380623

Reference yield:

methyl 12-bromododecanoate (26825-95-6) → 12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-1-{16-[12-(16-benzyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl)-dodecanoyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-dodecan-1-one (328934-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / Na₂CO₃; KI / various solvent(s) / 24 h / Heating

2: 90 percent / 2N NaOH / methanol / 24 h / Heating

3: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 2.33 h / 0 - 20 °C

4: 0.130 g / DMAP; Et₃N / CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium hydroxide; oxalyl dichloride; sodium carbonate; triethylamine; potassium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570380623

upstream raw materials:

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

7-benzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

12-Bromo-1-[16-(12-bromo-dodecanoyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl]-dodecan-1-one

12-bromododecanoic acid