(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

Base Information

Chemical Name:(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol
CAS No.:581782-99-2
Molecular Formula:C₁₆H₂₂O₆
Molecular Weight:310.347
Hs Code.:

Synonyms:(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

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Chemical Property of (+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

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Technology Process of (+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

There total 5 articles about (+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 581782-97-0
(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-one

: 581782-99-2
(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

Guidance literature:: With zinc(II) tetrahydroborate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja0347538

Reference yield:

: 33647-88-0
(R)-5-oxo-5,6-dihydro-2H-pyran-2-yl acetate

: 581782-99-2
(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium(II) acetate; triphenylphosphite / CH₂Cl₂

1.2: 98 percent / CH₂Cl₂

2.1: RuCl₃*3H₂O; aq. NaIO₄ / acetonitrile; ethyl acetate / 0.42 h

3.1: 130 mg / p-TsOH; 2,2-dimethoxypropane / 2 h / 20 °C

4.1: 88 percent / Zn(BH₄)2 / tetrahydrofuran; diethyl ether

With triphenyl phosphite; ruthenium trichloride; sodium periodate; zinc(II) tetrahydroborate; palladium diacetate; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/ja0347538

Reference yield:

: 62644-49-9
6-acetoxy-2H-pyran-3(6H)-one

: 581782-99-2
(+)-4-(3-methoxy-benzyloxy)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / n-butanol; Lipase PS-HSC / dioxane / 48 h / 20 °C

2.1: palladium(II) acetate; triphenylphosphite / CH₂Cl₂

2.2: 98 percent / CH₂Cl₂

3.1: RuCl₃*3H₂O; aq. NaIO₄ / acetonitrile; ethyl acetate / 0.42 h

4.1: 130 mg / p-TsOH; 2,2-dimethoxypropane / 2 h / 20 °C

5.1: 88 percent / Zn(BH₄)2 / tetrahydrofuran; diethyl ether

With triphenyl phosphite; ruthenium trichloride; sodium periodate; zinc(II) tetrahydroborate; Lipase PS-HSC; palladium diacetate; toluene-4-sulfonic acid; 2,2-dimethoxy-propane; butan-1-ol; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/ja0347538