(1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid
CAS No.:1402883-38-8
Molecular Formula:C₂₅H₃₁N₃O₇
Molecular Weight:485.537
Hs Code.:

Synonyms:(1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Suppliers and Price of (1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

There total 9 articles about (1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1402883-37-7
C₂₀H₂₃N₃O₅

: 1402883-38-8
(1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Guidance literature:: C₂₀H₂₃N₃O₅; With N,O-bis-(trimethylsilyl)-acetamide; at 20 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; With dmap; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm3011405

Reference yield:

: C₁₅H₁₄N₃O₃^(1-)*Na⁽¹⁺⁾

: 1402883-38-8
(1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: water; potassium hydroxide / ethanol / 4 h / 60 °C

4.1: N,O-bis-(trimethylsilyl)-acetamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C

With dmap; N,O-bis-(trimethylsilyl)-acetamide; water; potassium carbonate; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3011405

Reference yield:

: 96847-52-8
(1R,2S)-2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane

: 1402883-38-8
(1R,2S)-2-(2-(bis(tert-butoxycarbonyl)amino)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-phenylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol; water / 1 h / 20 °C

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 25 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

3.2: 20 - 80 °C

4.1: sodium ethanolate / ethanol / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: water; potassium hydroxide / ethanol / 4 h / 60 °C

8.1: N,O-bis-(trimethylsilyl)-acetamide / 0.5 h / 20 °C / Inert atmosphere

8.2: 1 h / 20 °C

With dmap; ruthenium trichloride; sodium periodate; N,O-bis-(trimethylsilyl)-acetamide; water; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405