3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine

Base Information

• Chemical Name: 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine
• CAS No.: 890659-41-3
• Molecular Formula: C₃₂H₄₉NO₅Si
• Molecular Weight: 555.83

Synonyms:3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine

Chemical Property of 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine

There total 11 articles about 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propionitrile (890659-23-1) → 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine (890659-41-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at 0 ℃;

DOI:10.1016/j.tetlet.2006.02.160

Reference yield:

C19H23NO4 (890659-18-4) → 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine (890659-41-3)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 99 percent / K₂CO₃ / tetrahydrofuran / 20 °C

2.1: 99 percent / imidazole / tetrahydrofuran / 20 °C

3.1: 95 percent / LiBH₄ / ethanol; diethyl ether / Heating

4.1: 99 percent / TBAF / tetrahydrofuran / 20 °C

5.1: 95 percent / NaH / dimethylformamide / 20 °C

6.1: 98 percent / PPTS / acetone; H₂O / Heating

7.1: NHMDS; TBDMSCl / tetrahydrofuran / 20 °C

7.2: NMO / OsO₄ / acetonitrile; H₂O / 20 °C

8.1: TMSCl / CH₂Cl₂ / 20 °C

8.2: 81 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

9.1: 82 percent / DIBAL-H / CH₂Cl₂ / 0 °C

With 1H-imidazole; lithium borohydride; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; tert-butyldimethylsilyl chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tetlet.2006.02.160

Reference yield:

C18H23NO4 (890659-20-8) → 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine (890659-41-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 95 percent / NaH / dimethylformamide / 20 °C

2.1: 98 percent / PPTS / acetone; H₂O / Heating

3.1: NHMDS; TBDMSCl / tetrahydrofuran / 20 °C

3.2: NMO / OsO₄ / acetonitrile; H₂O / 20 °C

4.1: TMSCl / CH₂Cl₂ / 20 °C

4.2: 81 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

5.1: 82 percent / DIBAL-H / CH₂Cl₂ / 0 °C

With chloro-trimethyl-silane; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; tert-butyldimethylsilyl chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tetlet.2006.02.160

upstream raw materials:

3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propionitrile

C₁₉H₂₃NO₄

C₁₈H₂₃NO₄

3-benzyloxy-2-benzyloxymethyl-2-(3-oxo-cyclohexyl)-propionitrile

Downstream raw materials:

2-({3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamino}-methyl)-phenol

5-[1,1-bis-benzyloxymethyl-2-(2-hydroxy-benzylamino)-ethyl]-2-hydroxy-cyclohexanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 890659-41-3 3-benzyloxy-2-benzyloxymethyl-2-[10-(tert-butyl-dimethyl-silanyloxy)-1,4-dioxa-spiro[4.5]dec-7-yl]-propylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send