1-(trifluoroMethyl)cyclohexanaMine hydrochloride

Base Information

• Chemical Name: 1-(trifluoroMethyl)cyclohexanaMine hydrochloride
• CAS No.: 134424-35-4
• Molecular Formula: C₇H₁₂F₃N
• Molecular Weight: 167.174
• Mol file: 134424-35-4.mol

Synonyms:1-trifluoromethyl-1-aminocyclohexane

Chemical Property of 1-(trifluoroMethyl)cyclohexanaMine hydrochloride

Chemical Property:

• Boiling Point: 112-114 °C(Press: 20 Torr)
• PKA: 6.40±0.70(Predicted)
• Density: 1.148±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

1-(Trifluoromethyl)cyclohexanaminehydrochloride 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(trifluoroMethyl)cyclohexanaMine hydrochloride

There total 4 articles about 1-(trifluoroMethyl)cyclohexanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-benzyl-1-(trifluoromethyl)cyclohexanamine (1100246-29-4) → 1-trifluoromethyl-1-aminocyclohexane (134424-35-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 37503.8 Torr;

DOI:10.1016/j.tetlet.2013.01.132

Reference yield:

N-benzylcyclohexylimine (4471-09-4) → 1-trifluoromethyl-1-aminocyclohexane (134424-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydrogen difluoride; trifluoroacetic acid / 12 h / 0 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 37503.8 Torr

With potassium hydrogen difluoride; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol;

DOI:10.1016/j.tetlet.2013.01.132

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-trifluoromethyl-1-aminocyclohexane (134424-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium hydrogen sulfate / dichloromethane / 96 h / 20 °C

2: potassium hydrogen difluoride; trifluoroacetic acid / 12 h / 0 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 37503.8 Torr

With potassium hydrogen difluoride; magnesium hydrogen sulfate; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.tetlet.2013.01.132

upstream raw materials:

N-benzylcyclohexylimine

N-benzyl-1-(trifluoromethyl)cyclohexanamine

cyclohexanone

Refernces

• 1、 -. "Fluorinated cyclohexane derivatives, process and intermediates for their preparation and the use of the new fluorinated cyclohexane derivatives as fungicides and intermediates". . . Retrieved 2008/06/13.